Individual mRNA expression profiles reveal the effects of specific microRNAs |
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| Authors: | Amit Arora David AC Simpson |
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| Affiliation: | (1) Queen's University Belfast, Centre for Vision Sciences, Institute of Clinical Science, Royal Victoria Hospital, Belfast, BT12 6BA, UK |
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| Abstract: | Background MicroRNAs (miRNAs) are oligoribonucleotides with an important role in regulation of gene expression at the level of translation. Despite imperfect target complementarity, they can also significantly reduce mRNA levels. The validity of miRNA target gene predictions is difficult to assess at the protein level. We sought, therefore, to determine whether a general lowering of predicted target gene mRNA expression by endogenous miRNAs was detectable within microarray gene expression profiles. |
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