Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness |
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| Authors: | Hashimoto Koichi Graham Barney S Geraci Mark W FitzGerald Garret A Egan Karine Zhou Weisong Goleniewska Kasia O'Neal Jamye F Morrow Jason D Durbin Russell K Wright Peter F Collins Robert D Suzutani Tatsuo Peebles R Stokes |
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| Affiliation: | Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA. |
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| Abstract: | The role of prostanoids in modulating respiratory syncytial virus (RSV) infection is unknown. We found that RSV infection in mice increases production of prostaglandin I(2) (PGI(2)). Mice that overexpress PGI(2) synthase selectively in bronchial epithelium are protected against RSV-induced weight loss and have decreased peak viral replication and gamma interferon levels in the lung compared to nontransgenic littermates. In contrast, mice deficient in the PGI(2) receptor IP have exacerbated RSV-induced weight loss with delayed viral clearance and increased levels of gamma interferon in the lung compared to wild-type mice. These results suggest that signaling through IP has antiviral effects while protecting against RSV-induced illness and that PGI(2) is a potential therapeutic target in the treatment of RSV. |
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