Arginine-glycine-aspartic acid motif is critical for human parechovirus 1 entry |
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| Authors: | Boonyakiat Y Hughes P J Ghazi F Stanway G |
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| Affiliation: | Department of Biological Sciences, John Tabor Laboratories, University of Essex, Colchester CO4 3SQ, United Kingdom. |
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| Abstract: | The human parechovirus 1 RGD motif in VP1 was studied by mutagenesis. An RGD-to-RGE change gave only revertant viruses with a restored RGD, while deletion of GD was lethal and nonrevertable. Mutations at the +1 and +2 positions had some effect on growth properties and a +1 M-to-P change was lethal. These studies indicate that the RGD motif plays a critical role in infectivity, presumably by interacting with integrins, and that downstream amino acids can have an influence on function. |
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