PhoP can activate its target genes in a PhoQ-independent manner |
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| Authors: | Lejona Sergio Castelli María Eugenia Cabeza María Laura Kenney Linda J García Véscovi Eleonora Soncini Fernando C |
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| Affiliation: | Departamento de Microbiología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Instituto de Biología Molecular y Celular de Rosario, Consejo Nacional de Investigaciones Científicas y Técnicas, 2000 Rosario, Argentina. |
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| Abstract: | The PhoP/PhoQ two-component system controls the extracellular magnesium depletion response in Salmonella enterica. Previous studies have shown that PhoP is unable to up-regulate its target genes in the absence of PhoQ function. In this work, we demonstrate that PhoP overexpression can substitute for PhoQ- and phosphorylation-dependent activation. Either a high concentration of PhoP or activation via phosphorylation stimulates PhoP self-association. |
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