| 短链脂肪酸对肠黏膜屏障的影响 |
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| 引用本文： | 王春敏, 韩桂华, 马淑霞. 短链脂肪酸对肠黏膜屏障的影响[J]. 中国微生态学杂志, 2022, 34(12): 1471-1475. doi: 10.13381/j.cnki.cjm.202212020 |
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| 作者姓名： | 王春敏 韩桂华 马淑霞 |
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| 作者单位： | 1. 佳木斯大学基础医学院微生物教研室，黑龙江 佳木斯 154007; 2. 佳木斯大学第一附属医院，黑龙江 佳木斯 154007 |
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| 基金项目： | 佳木斯大学专业认证专项项目（2018RZZX-013） |
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| 摘 要： | 肠黏膜屏障具有将致病性抗原等肠内物质与内环境隔离的功能，以维持内环境的相对稳定和机体的正常生命活动。其功能的维持依赖于人肠黏膜上皮细胞、肠道内正常菌群、肠道内分泌物和肠相关免疫细胞之间的功能协调，而其功能的发挥又受体内许多信号分子的影响。短链脂肪酸（short-chain fatty acids，SCFAs）就是其中一种重要的信号分子。SCFAs是肠道菌群的主要代谢产物之一，是肠道菌群与宿主代谢相互作用的媒介。宿主体内的SCFAs主要来自肠道菌群对膳食纤维的酵解，越来越多的研究证实，SCFAs不仅可以被肠道菌群利用，还可调节肠黏膜屏障及多种组织器官的代谢。本文主要就SCFAs对肠黏膜屏障的影响进行综述。
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| 关 键 词： | 短链脂肪酸 肠黏膜屏障 肠道菌群 |
| 收稿时间： | 2021-01-21 |
| 修稿时间： | 2021-03-27 |
Effects of short-chain fatty acids on intestinal mucosal barrier |
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| WANG Chun-min, HAN Gui-hua, MA Shu-xia. Effects of short-chain fatty acids on intestinal mucosal barrier[J]. Chinese Journal of Microecology, 2022, 34(12): 1471-1475. doi: 10.13381/j.cnki.cjm.202212020 |
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| Authors: | WANG Chun-min HAN Gui-hua MA Shu-xia |
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| Affiliation: | 1. Microbiology Department of Jiamusi University, Jiamusi, Heilongjiang 154007, China |
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| Abstract: | Intestinal mucosal barrier has the function of isolating pathogenic antigens and other intestinal substances from the internal environment, so as to maintain the relative stability of the internal environment and normal life activities of the body. The maintenance of intestinal barrier function depends on the functional coordination among human intestinal epithelium, normal intestinal flora, intestinal secretions and intestinal related immune cells, while its function is affected by many signaling molecules in the body. Short-chain fatty acids (SCFAs) are one of the important signaling molecules. SCFAs are one kind of important metabolites of intestinal flora, and the medium of metabolic interaction between intestinal flora and host. SCFAs in host mainly come from the digestion of dietary fibers by intestinal flora. More and more studies have confirmed that SCFAs can not only be used by intestinal flora, but also regulate intestinal mucosal barrier and metabolisms of many tissues and organs. This literary review mainly discusses the effect of SCFAs on intestinal mucosal barrier. |
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| Keywords: | Short chain fatty acids Intestinal mucosal barrier Intestinal flora |
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