Pathogenic conversion of live attenuated simian immunodeficiency virus vaccines is associated with expression of truncated Nef |
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| Authors: | Sawai E T Hamza M S Ye M Shaw K E Luciw P A |
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| Affiliation: | Department of Medical Pathology, University of California, Davis, California 95616, USA. |
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| Abstract: | Rhesus macaques infected with simian immunodeficiency virus (SIV) containing either a large nef deletion (SIVmac239Delta(152)nef) or interleukin-2 in place of nef developed high virus loads and progressed to simian AIDS. Viruses recovered from both juvenile and neonatal macaques with disease produced a novel truncated Nef protein, tNef. Viruses recovered from juvenile macaques infected with serially passaged virus expressing tNef exhibited a pathogenic phenotype. These findings demonstrated strong selective pressure to restore expression of a truncated Nef protein, and this reversion was linked to increased pathogenic potential in live attenuated SIV vaccines. |
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