Acanthamoeba castellanii promotion of in vitro survival and transmission of coxsackie b3 viruses |
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| Authors: | Mattana A Serra C Mariotti E Delogu G Fiori P L Cappuccinelli P |
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| Affiliation: | Dipartimento di Scienze del Farmaco, Via Muroni 23/A, 07100 Sassari, Italy. dsfanto@uniss.it |
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| Abstract: | This work was undertaken to determine whether Acanthamoeba could play a role in the survival and transmission of coxsackieviruses and focused on in vitro interactions between Acanthamoeba castellanii and coxsackie B3 viruses (CVB-3). Residual virus titer evaluations and immunofluorescence experiments revealed a remarkable CVB-3 adsorption on amoeba surfaces and accumulation inside cells. The survival of viruses was independent of the dynamics of amoeba replication and encystment. In addition, our results indicated that virus-infected amoebas can release infectious viruses during interaction with human macrophages. On the basis of these data, Acanthamoeba appears to be a potential promoter of the survival of coxsackieviruses and their transmission to human hosts. |
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