Proteolytic processing of the Ebola virus glycoprotein is not critical for Ebola virus replication in nonhuman primates |
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| Authors: | Neumann Gabriele Geisbert Thomas W Ebihara Hideki Geisbert Joan B Daddario-DiCaprio Kathleen M Feldmann Heinz Kawaoka Yoshihiro |
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| Affiliation: | Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 2015 Linden Drive, Madison, WI 53706, USA. |
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| Abstract: | Enveloped viruses often require cleavage of a surface glycoprotein by a cellular endoprotease such as furin for infectivity and virulence. Previously, we showed that Ebola virus glycoprotein does not require the furin cleavage motif for virus replication in cell culture. Here, we show that there are no appreciable differences in disease progression, hematology, serum biochemistry, virus titers, or lethality in nonhuman primates infected with an Ebola virus lacking the furin recognition sequence compared to those infected with wild-type virus. We conclude that glycoprotein cleavage by subtilisin-like endoproteases is not critical for Ebola virus infectivity and virulence in nonhuman primates. |
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