| iPS细胞的遗传安全性 |
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| 引用本文： | 陈倩,史庆华. iPS细胞的遗传安全性[J]. 遗传, 2012, 34(3): 260-268. DOI: 10.3724/SP.J.1005.2012.00260 |
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| 作者姓名： | 陈倩 史庆华 |
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| 作者单位： | 中国科学技术大学生命科学学院, 合肥微尺度物质科学国家实验室, 合肥 230027 |
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| 基金项目： | 中国科学院"百人计划"项目,国家自然科学基金项目 |
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| 摘 要： | 自2006年Takahashi和Yamanaka首次成功地从小鼠成纤维细胞诱导得到诱导多能性干细胞(Induced pluripotent stem cells, iPS细胞)以来, iPS细胞由于其潜在的广阔应用前景而迅速成为干细胞研究领域的新热点; 与此同时, iPS细胞的遗传安全性也越来越多地受到人们的关注。文章将对iPS细胞遗传安全性的研究进展进行综述, 分析造成iPS细胞遗传不稳定的可能原因, 希望可以促进对iPS细胞诱导条件的优化, 获得遗传上较为安全的iPS细胞。
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| 关 键 词： | iPS细胞 遗传安全性 遗传不稳定 遗传异常 表观遗传异常 |
| 收稿时间： | 2011-11-16 |
The genetic safety of induced pluripotent stem (iPS) cells |
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| Affiliation: | Hefei National Laboratory for Physical Sciences at Microscale, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China |
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| Abstract: | Since Takahashi and Yamanaka first generated induced pluripotent stem (iPS) cells from mouse fibroblasts successfully in 2006, iPS cells have rapidly become a new hotspot in the field of stem cells research because of their broad potential application prospects. Meanwhile, more and more attentions are paid to the genetic safety of iPS cells. This article summarizes recent findings on genetic safety of iPS cells and reviews the possible causes leading to genetic instability of iPS cells. Hopefully, this review is helpful to improve the induction of iPS cells and obtain genetically safe iPS cells. |
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| Keywords: | epigenetic abnormality iPS cells genetic safety genetic instability genetic abnormality |
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