Enantioselective Ethylation of Various Aldehydes Catalyzed by Readily Accessible Chiral Diols |
| |
| Authors: | Yaşar Gök Seda Kiliçarslan Halil Zeki Gök İlker Ümit Karayiğit |
| |
| Affiliation: | Department of Chemistry, Faculty of Arts and Sciences, Osmaniye Korkut Ata University, Osmaniye, Turkey |
| |
| Abstract: | Four chiral C2‐symmetric diols were synthesized in a straightforward three‐step reaction and demonstrated excellent enantioselectivities and good overall yields. Their catalytic activities were examined via the addition of diethylzinc to various aldehydes. The enantioselective addition of diethylzinc to 2‐methoxybenzaldehyde gave the corresponding chiral secondary alcohol with high yields (up to 95%) and moderate to good enantiomeric excess (up to 88%). All synthesized ligands were evaluated in the addition of diethylzinc to various aldehydes in the presence of an additional metal such as Ti(IV) complexes. Chirality 28:593–598, 2016. © 2016 Wiley Periodicals, Inc. |
| |
| Keywords: | chiral diols enantioselectivity catalysis C2‐symmetric diethylzinc addition |
|
