Chiral separation on various modified amino alcohol‐derived HPLC chiral stationary phases |
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| Authors: | Jeongjae Yu Jung Mi Lee Jae Jeong Ryoo |
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| Affiliation: | 1. Department of Chemistry, Kyungpook National University, Daegu, Korea;2. Department of Chemistry Education, Kyungpook National University, Daegu, Korea |
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| Abstract: | 3,5‐Dinitrobenzoyl chloride was previously used for the preparation of (R)‐phenylglycinol‐ and (S)‐leucinol‐derived chiral stationary phases. In this study, 3,5‐bis(trifluoromethyl)benzoyl chloride, 2‐furoyl chloride, 2‐theonyl chloride, 10,11‐dihydro‐5H‐dibenzo[b,f]azepine‐5‐carbonyl chloride, diphenylcarbamoyl chloride, and 1‐adamantanecarbonyl chloride were used to prepare six new phenylglycinol‐derived chiral stationary phases (CSPs) and five new leucinol‐derived CSPs. Using these 11 CSPs, chiral separation of nine π‐acidic amino acid derivatives and five π‐basic compounds was performed, and the separation results were compared. An adamantyl‐derived CSP showed good separation. Chirality 28:276–281, 2016. © 2016 Wiley Periodicals, Inc. |
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| Keywords: | (R)‐phenylglycinol (S)– leucinol chiral stationary phase adamantyl‐derived CSP different acid chlorides |
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