Refined genetic mapping of X-linked Charcot-Marie-Tooth neuropathy. |
| |
| Authors: | P. R. Fain D. F. Barker P. F. Chance |
| |
| Affiliation: | Department of Medical Informatics, University of Utah School of Medicine, Salt Lake City 84108. |
| |
| Abstract: | Genetic linkage studies were conducted in four multigenerational families with X-linked Charcot-Marie-Tooth disease (CMTX), using 12 highly polymorphic short-tandem-repeat markers for the pericentromeric region of the X chromosome. Pairwise linkage analysis with individual markers confirmed tight linkage of CMTX to the pericentromeric region in each family. Multipoint analyses strongly support the order DXS337-CMTX-DXS441-(DXS56,PGK1). |
| |
| Keywords: | |
|
|
