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Leptin induces MMP1/13 and ADAMTS 4 expressions through bone morphogenetic protein‐2 autocrine effect in human chondrocytes
Authors:Yu‐Ping Su  Cheng‐Nan Chen  Kuo‐Chin Huang  Hsin‐I Chang  Ko‐Chao Lee  Chun‐Min Lo  Shun‐Fu Chang
Affiliation:1. Department of Orthopaedics and Traumatology, Veterans General Hospital, Taipei, Taiwan;2. Department of Surgery, School of Medicine, National Yang‐Ming University, Taipei, Taiwan;3. Department of Biomedical Engineering, National Yang‐Ming University, Taipei, Taiwan;4. Department of Biochemical Science and Technology, National Chiayi University, Chiayi, Taiwan;5. Department of Orthopaedics, Chang Gung Memorial Hospital Chiayi Branch, Chiayi, Taiwan;6. Division of Colorectal Surgery, Department of Surgery, Chang Gung Memorial Hospital‐Kaohsiung Medical Center, Kaohsiung, Taiwan;7. Department of Medical Research and Development, Chang Gung Memorial Hospital Chiayi Branch, Chiayi, Taiwan
Abstract:
Keywords:ADAMTS  BMP2  chondrocytes  leptin  MMP
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