The yggH gene of Escherichia coli encodes a tRNA (m7G46) methyltransferase |
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| Authors: | De Bie Lara G S Roovers Martine Oudjama Yamina Wattiez Ruddy Tricot Catherine Stalon Victor Droogmans Louis Bujnicki Janusz M |
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| Affiliation: | Laboratoire de Microbiologie, Université Libre de Bruxelles, B-1070 Brussels, Belgium. |
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| Abstract: | We cloned, expressed, and purified the Escherichia coli YggH protein and show that it catalyzes the S-adenosyl-L-methionine-dependent formation of N(7)-methylguanosine at position 46 (m(7)G46) in tRNA. Additionally, we generated an E. coli strain with a disrupted yggH gene and show that the mutant strain lacks tRNA (m(7)G46) methyltransferase activity. |
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