Functional impairment of simian immunodeficiency virus-specific CD8+ T cells during the chronic phase of infection |
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| Authors: | Vogel T U Allen T M Altman J D Watkins D I |
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| Affiliation: | Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715 , USA. |
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| Abstract: | In an attempt to determine why high frequencies of circulating virus-specific CD8+ T cells are unable to control human immunodeficiency virus and simian immunodeficiency virus (SIV) replication, we assessed the functional nature of SIV-specific CD8+ lymphocytes. After vaccination and early after infection, nearly all tetramer-staining CD8+ cells produced gamma interferon in response to their specific stimulus. However, by 4 months postinfection with pathogenic SIVmac239, signs of functional impairment in the CD8+ T-cell compartment were detected which might prevent these T cells from efficiently controlling the infection during the chronic phase. |
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