Piptadenin,a Novel 3,4‐Secooleanane Triterpene and Piptadenamide,a New Ceramide from the Stem Bark of Piptadeniastrum africanum (Hook.f.) Brenan |
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| Authors: | Amadou Dawé Marius Mbiantcha Yannick Fongang William Yosseu Nana Fawai Yakai Gilbert Ateufack Muhammad Ali Shaiq Iqbal Lubna Mehreen Lateef Bonaventure Tchaleu Ngadjui |
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| Affiliation: | 1. Department of Chemistry, Higher Teachers Training College, University of Maroua, Maroua, Cameroon;2. Department of Biology, Faculty of Science, University of Dschang, Dschang, Cameroon;3. International Center for Chemical and Biological Sciences, University of Karachi, Karachi, Pakistan;4. PCSIR Laboratories Karachi Complex, Pharmaceutical Research Center, Karachi, Pakistan;5. Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé, Cameroon |
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| Abstract: | Piptadenin ( 1 ), a new triterpene along with piptadenamide ( 10 ), a new ceramide, have been isolated from the AcOEt‐soluble fraction of the MeOH extract of the stem bark of Piptadeniastrum africanum along with nine known compounds, 1‐O‐[(3β,22β)‐3,22‐dihydroxy‐28‐oxoolean‐12‐en‐28‐yl]‐β‐d ‐glucopyranose ( 2 ), 22β‐hydroxyoleanic acid ( 3 ), oleanic acid ( 4 ), lupeol ( 5 ), betulinic acid ( 6 ), 5α‐stigmasta‐7,22‐dien‐3β‐ol ( 7 ), 5α‐stigmasta‐7,22‐dien‐3‐one ( 8 ), (3β)‐stigmast‐5‐en‐3‐yl β‐d ‐glucopyranoside ( 9 ) and 2,3‐dihydroxypropyl hexacosanoate ( 11 ). Except for compound 11 , all the isolated compounds are reported for the first time from this plant. The structures of the isolated compounds were elucidated by spectroscopic data including 1D and 2D NMR. The pure compounds 1 – 11 were subjected to the pharmacological screening and compounds 2 , 5 – 7 and 9 exhibited potent urease inhibitory activity with IC50 value of 25.8, 28.9, 30.1, 31.8 and 32.7 μm , respectively, whereas compound 1 showed moderate activity (IC50 = 98.7 μm ). The potent urease inhibitory activity supplemented the previous literature reports and medicinal uses of this plant. |
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| Keywords: |
Piptadeniastrum africanum
Leguminosae 3,4‐Secooleanane triterpene Ceramide Urease inhibition |
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