Dynamics of T-cell responses and memory T cells during primary simian immunodeficiency virus infection in cynomolgus macaques |
| |
| Authors: | Karlsson Ingrid Malleret Benoît Brochard Patricia Delache Benoît Calvo Julien Le Grand Roger Vaslin Bruno |
| |
| Affiliation: | Ingrid Karlsson, Benoît Malleret, Patricia Brochard, Benoît Delache, Julien Calvo, Roger Le Grand, and Bruno Vaslin |
| |
| Abstract: | Cellular immune responses make an important contribution to both the control of human immunodeficiency virus (HIV) replication and disease progression. We used a pathogenic model of SIVmac251 infection of cynomolgus macaques to longitudinally evaluate cellular immune responses in association with various rates of disease progression. We found an inverse relationship between plasma viral load and the simian immunodeficiency virus (SIV)-specific T cells responses in peripheral blood and lymph nodes. SIV-specific T-cell responses in peripheral blood were transient during primary infection, with the highest responses detected around 3 months after infection. There was also a transient increase of central memory CD8+ T cells in peripheral blood during primary infection, and effector memory T-cell counts in peripheral lymph nodes were increased. This study emphasizes the importance of the early virus-specific immune responses in the outcome of HIV/SIV disease and provides details about the changes of virus-specific immune responses over time. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
