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Species Barrier Prevents an Abnormal Isoform of Prion Protein from Accumulating in Follicular Dendritic Cells of Mice with Creutzfeldt-Jakob Disease |
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| Authors: | Tamaki Muramoto Tetsuyuki Kitamoto Mohammad Zahirul Hoque Jun Tateishi Ikuo Goto |
| Abstract: | The accumulation of abnormal prion protein in follicular dendritic cells did not occur in mice inoculated with materials from human Creutzfeldt-Jakob disease, whereas it always occurred in mice inoculated with mouse-adapted agents, suggesting an intense expression of the species barrier in the lymphoreticular system. |
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