| 药用植物分子农场研究进展 |
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| 引用本文： | 孙卉,张春义,姜凌. 药用植物分子农场研究进展[J]. 生物技术进展, 2023, 13(1): 65-71. DOI: 10.19586/j.2095-2341.2022.0156 |
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| 作者姓名： | 孙卉 张春义 姜凌 |
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| 作者单位： | 中国农业科学院生物技术研究所，北京 100081 |
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| 基金项目： | 国家自然科学基金项目(31870283);中国农业科学院创新工程项目(CAAS-ZDRW202010) |
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| 摘 要： | 植物分子农场可以利用植物生产具有药物用途的重组蛋白或者次生代谢化合物，应用广泛。随着对动植物中具有药物用途的代谢途径的深入解析，代谢途径中关键限速酶或调控蛋白的功能不断被明确，如何选择植物分子农场的底盘植物和遗传改造途径等问题，特别是如何协同提高植物制药产量与品质一直是植物分子农场体系建立中面临的关键科学问题。综述了药用的植物分子农场的最新研究进展，着重介绍了底盘植物的选择与药用植物分子农场的构建策略，以期为提高分子农场应用效果提供有力的科技支撑。
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| 关 键 词： | 药用成分 植物分子农场 蛋白设计 基因编辑 |
| 收稿时间： | 2022-09-01 |
Progress of Plant Molecular Farming in Pharmaceutical Use |
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| Hui SUN,Chunyi ZHANG,Ling JIANG. Progress of Plant Molecular Farming in Pharmaceutical Use[J]. CURRENT BIOTECHNOLOGY, 2023, 13(1): 65-71. DOI: 10.19586/j.2095-2341.2022.0156 |
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| Authors: | Hui SUN Chunyi ZHANG Ling JIANG |
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| Affiliation: | Biotechnology Research Institute，Chinese Academy of Agricultural Sciences，Beijing 100081，China |
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| Abstract: | Plant molecular farming producing recombinant proteins or secondary metabolic compounds of pharmaceutical uses has great potential to be widely used in different therapeutical situation. With the continuous progress of metabolic pathways involved in pharmaceutical uses in animals and plants， more and more key rate-limiting enzymes or regulatory proteins have been identified. However， how to select the baseplate plant and genetic transformation methods， especially， how to ef?ciently manufacture high quality of pharmaceuticals from plants and improve the yield has always been one of the key scientific issues. This paper reviewed the key factors for the establishment of plant molecular farming， focued on the application of new technologies such as protein molecular design and gene editing involved in the process， and put forward the latest strategies for the establishment of plant molecular farms， and provided scientific and technological support for improving the efficiency of molecular farms of pharmaceutical uses. |
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| Keywords: | pharmaceutical uses plant molecular farming protein design gene editing |
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