|
|||||
|
|
Targeted expression of Cre recombinase to adipose tissue of transgenic mice directs adipose-specific excision of loxP-flanked gene segments. |
|
| Authors: | C Barlow M Schroeder J Lekstrom-Himes H Kylefjord C X Deng A Wynshaw-Boris B M Spiegelman K G Xanthopoulos |
| Abstract: | Functional analysis of mammalian genes relies, in part, on targeted mutations generated by homologous recombination in mice. We have developed a strategy for adipose-specific inactivation of loxP-floxed gene segments. Transgenic mice have been established that express Cre recombinase under the control of the adipose-specific aP2 enhancer/promoter. Crossing of the aP2/ Cre mice with any loxP-floxed gene will facilitate its functional analysis in adipose tissue. |
| Keywords: | |