Role of motility in adherence to and invasion of a fish cell line by Vibrio anguillarum |
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Authors: | Ormonde P Hörstedt P O'Toole R Milton D L |
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Affiliation: | Department of Cell and Molecular Biology1. and Department of Medical Biosciences, Pathology,2. Umeå University, S-901 87 Umeå, Sweden |
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Abstract: | To understand further the role of the flagellum of Vibrio anguillarum in virulence, invasive and adhesive properties of isogenic motility mutants were analyzed by using a chinook salmon embryo cell line. Adhesion was unaffected but invasion of the cell line was significantly decreased in nonmotile or partially motile mutants, and the chemotactic mutant was hyperinvasive. These results suggest that active motility aids invasion by V. anguillarum, both in vivo and in vitro. |
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