Induction of polyomavirus-specific CD8(+) T lymphocytes by distinct dendritic cell subpopulations |
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| Authors: | Drake D R Shawver M L Hadley A Butz E Maliszewski C Lukacher A E |
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| Affiliation: | Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA. |
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| Abstract: | Dendritic cells are pivotal antigen-presenting cells for generating adaptive T-cell responses. Here, we show that dendritic cells belonging to either the myeloid-related or lymphoid-related subset are permissive for infection by mouse polyomavirus and, when loaded with a peptide corresponding to the immunodominant anti-polyomavirus CD8(+) T-cell epitope or infected by polyomavirus, are each capable of driving expansion of primary polyomavirus-specific CD8(+) T-cell responses in vivo. |
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