Differential gene expression of the key signalling pathway in para‐carcinoma,carcinoma and relapse human pancreatic cancer |
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| Authors: | Zheng‐Yan Chang Ran Sun Yu‐Shui Ma Da Fu Xiao‐Long Lai Yu‐Sheng Li Xing‐Hong Wang Xiao‐Ping Zhang Zhong‐Wei Lv Xian‐Ling Cong Wen‐Ping Li |
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| Affiliation: | 1. Veterinary Faculty, College of Veterinary Medicine, Hunan Agricultural University, Changsha, China;2. Tissue Bank, China‐Japan Union Hospital, Jilin University, Changchun, China;3. Department of Nuclear Medicine, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China;4. Department of Orthopedic, Xiangya Hospital, Central‐South University, Changsha, China;5. Department of Endoscorpic Inventiona, General Hospital of Administration Bureau for Petrolium of North China, Renqiu, China;6. Department of Dermatology, China‐Japan Union Hospital, Jilin University, Changchun, China |
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| Abstract: | Pancreatic cancer (PC) has a high rate of mortality and a poorly understood mechanism of progression. Investigation of the molecular mechanism of PC and exploration of the specific markers for early diagnosis and specific targets of therapy are key points to prevent and treat PC effectively and to improve their prognosis. In our study, expression profiles experiment of para‐carcinoma, carcinoma and relapse human PC was performed using Agilent human whole genomic oligonucleotide microarrays with 45 000 probes. Differentially expressed genes related with PC were screened and analysed further by Gene Ontology term analysis and Kyoto encyclopaedia of genes and genomes pathway analysis. Our results showed that there were 3853 differentially expressed genes associated with pancreatic carcinogenesis and relapse. In addition, our study found that PC was related to the Jak–STAT signalling pathway, PPAR signalling pathway and Calcium signalling pathway, indicating their potential roles in pancreatic carcinogenesis and progress. Copyright © 2013 John Wiley & Sons, Ltd. |
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| Keywords: | pancreatic cancer carcinogenesis relapse microarray Jak– STAT signalling pathway PPAR signalling pathway calcium signalling pathway |
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