The use of subchromosome-length unique band sequences in the analysis of prophase chromosomes. |
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| Authors: | D H Lockwood D A Johnston V M Riccardi S O Zimmerman |
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| Affiliation: | Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston. |
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| Abstract: | Using human prophase chromosome ideograms at the 850-band stage, we previously demonstrated that the 24 prophase ideograms can be divided into a set of 94 unique band sequences, each having a recognizable banding pattern distinct from other nonhomologous chromosome portions. Using actual prophase mitotic cells in this study, we analyzed the p arm of chromosome 11 and of chromosomes 16-22 and characterized a similar set of unique band sequences on actual chromosomes. This set of unique band sequences, a statistical comparison scheme, and image-processing techniques outlined in the present report can be used to identify and distinguish banding patterns of these chromosomes and to determine band pattern abnormalities. |
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