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Conversion of pepsinogen into pepsin is not a one-step process. |
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| Authors: | C W Dykes and J Kay |
| Abstract: | By incubation of pepsinogen with pepstatin at pH2.5, the first 'active' protein generated on activation is trapped in an inactive complex. The first activation peptide liberated has been identified as residues 1-16 from the pepsinogen sequence. This suggests a sequential mechanism rather than a one-step formation of pepsin. |
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