Spontaneous telangiectatic osteosarcoma in a rhesus macaque (Macaca mulatta) |
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| Authors: | B. Goldschmidt M.I.Z. Calado F.C. Resende R.M. Caldas L.W. Pinto C.A.A. Lopes F.G.O. França B.S. Meireles I.V. Souza |
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| Affiliation: | 1. Servi?o de cria??o de primatas n?o humanos, Instituto de Ciência e Tecnologia em Biomodelos (ICTB), Funda??o Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Brazil;2. Laboratório de Pesquisa Clínica em Dermatozoonoses em Animais Domésticos, Instituto Nacional de Infectologia Evandro Chagas, Funda??o Oswaldo Cruz, Rio de Janeiro, RJ, Brazil;3. Divis?o de Patologia, Instituto Nacional de Cancer, Rio de Janeiro, RJ, Brazil;4. Setor de radiologia, Nacional de Infectologia Evandro Chagas, Funda??o Oswaldo Cruz, Rio de Janeiro, RJ, Brazil |
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| Abstract: | Osteosarcoma (OS) is the most common type of bone cancer, especially in young. Telangiectatic osteosarcoma (TO) is a rare variant of OS, and hence, its occurrence, presentation, and prognosis are poorly understood. A 4‐year‐old female rhesus monkey presenting lameness and swelling was examined for a mass on the right humerus. Radiography revealed fracture and disorganized structure of bone tissue. Histopathological examination revealed malignant neoplasm composed of anaplastic osteoblasts, which invaded the bone marrow and surrounded blood‐filled cysts in the epiphysis and diaphysis forming septa. Cytogenetic analysis showed aneuploid cells, supernumerary AgNORs, and a marker fragment. The neoplasm was diagnosed as TO. To our knowledge, the occurrence of TO and its cytogenetic analysis were reported for the first time in non‐human primates. |
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| Keywords: | bone cancer chromosomes non‐human primate osteosarcoma |
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