|
|||||
|
|
Compensatory mutation partially restores fitness and delays reversion of escape mutation within the immunodominant HLA-B*5703-restricted Gag epitope in chronic human immunodeficiency virus type 1 infection |
|
| Authors: | Crawford Hayley Prado Julia G Leslie Alasdair Hué Stéphane Honeyborne Isobella Reddy Sharon van der Stok Mary Mncube Zenele Brander Christian Rousseau Christine Mullins James I Kaslow Richard Goepfert Paul Allen Susan Hunter Eric Mulenga Joseph Kiepiela Photini Walker Bruce D Goulder Philip J R |
| Affiliation: | Department of Pediatrics, University of Oxford, Peter Medawar Building for Pathogen Research, South Parks Rd., Oxford OX1 3SY, United Kingdom. |
| Abstract: | HLA-B*5703 is associated with effective immune control in human immunodeficiency virus type 1 (HIV-1) infection. Here we describe an escape mutation within the immunodominant HLA-B*5703-restricted epitope in chronic HIV-1 infection, KAFSPEVIPMF (Gag 162-172), and demonstrate that this mutation reduces viral replicative capacity. Reversion of this mutation following transmission to HLA-B*5703-negative recipients was delayed by the compensatory mutation S165N within the same epitope. These data may help explain the observed association between HLA-B*5703 and long-term control of viremia. |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ | |