|
|||||
|
|
GeneCount: genome-wide calculation of absolute tumor DNA copy numbers from array comparative genomic hybridization data |
|
| Authors: | Heidi Lyng Malin Lando Runar S Brøvig Debbie H Svendsrud Morten Johansen Eivind Galteland Odd T Brustugun Leonardo A Meza-Zepeda Ola Myklebost Gunnar B Kristensen Eivind Hovig Trond Stokke |
| Affiliation: | Heidi Lyng, Malin Lando, Runar S Brøvig, Debbie H Svendsrud, Morten Johansen, Eivind Galteland, Odd T Brustugun, Leonardo A Meza-Zepeda, Ola Myklebost, Gunnar B Kristensen, Eivind Hovig, and Trond Stokke |
| Abstract: | Absolute tumor DNA copy numbers can currently be achieved only on a single gene basis by using fluorescence in situ hybridization (FISH). We present GeneCount, a method for genome-wide calculation of absolute copy numbers from clinical array comparative genomic hybridization data. The tumor cell fraction is reliably estimated in the model. Data consistent with FISH results are achieved. We demonstrate significant improvements over existing methods for exploring gene dosages and intratumor copy number heterogeneity in cancers. |
| Keywords: | |
| 本文献已被 PubMed SpringerLink 等数据库收录！ | |