Inhibition of SV40 gene expression by microinjected small antisense RNA and DNA molecules |
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| Authors: | M. Graessmann G. Michaels B. Berg A. Graessmann |
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| Affiliation: | Institut für Molekularbiologie und Biochemie der Freien Universit?t Berlin, FRG. |
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| Abstract: | We tested the impact of antisense RNA and DNA molecules on SV40 gene expression by microinjection into TC7 cells. Short antisense stretches, complementary to either hairpin or loop structures on the T antigen mRNA, inhibited T antigen synthesis. In contrast, full-length antisense RNA and DNA molecules did not effect T antigen synthesis. |
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