Rotavirus-specific cytotoxic T lymphocytes passively protect against gastroenteritis in suckling mice. |
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| Authors: | P A Offit and K I Dudzik |
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| Affiliation: | Division of Infectious Diseases, Children's Hospital of Philadelphia, Pennsylvania. |
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| Abstract: | Suckling mice are protected against murine rotavirus-induced gastroenteritis after adoptive transfer of splenic lymphocytes from immunized animals. Adoptive transfer of Thy1(+)-depleted or CD8(+)-depleted lymphocytes abrogated protection against challenge. (We previously found that depletion of Thy1+ or CD8+ lymphocytes from rotavirus-immunized mice decreased rotavirus-specific cytotoxic activity in vitro.) Protection against disease occurred in the absence of rotavirus-specific neutralizing antibodies in the sera of suckling mice. Rotavirus-specific cytotoxic T lymphocytes may be important in either amelioration of acute infection or protection against reinfection. |
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