Severe acute respiratory syndrome coronavirus protein 6 mediates ubiquitin-dependent proteosomal degradation of N-Myc(and STAT) interactor |
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| Authors: | Weijia Cheng Shiyou Chen Ruiling Li Yu Chen Min Wang Deyin Guo |
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| Affiliation: | 1.School of Basic Medical Sciences, Wuhan University, Wuhan 430072, China2.College of Life Sciences, Wuhan University, Wuhan 430072, China |
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| Abstract: | Severe acute respiratory syndrome coronavirus(SARS-Co V) encodes eight accessory proteins, the functions of which are not yet fully understood. SARS-Co V protein 6(P6) is one of the previously studied accessory proteins that have been documented to enhance viral replication and suppress host interferon(IFN) signaling pathways. Through yeast two-hybrid screening, we identified eight potential cellular P6-interacting proteins from a human spleen c DNA library. For further investigation, we targeted the IFN signaling pathway-mediating protein, N-Myc(and STAT) interactor(Nmi). Its interaction with P6 was confirmed within cells. The results showed that P6 can promote the ubiquitin-dependent proteosomal degradation of Nmi. This study revealed a new mechanism of SARS-Co V P6 in limiting the IFN signaling to promote SARS-Co V survival in host cells. |
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| Keywords: | severe acute respiratory syndrome coronavirus (SARS-CoV) P6 N-Myc (and STAT) interactor (Nmi) interferon (IFN) signaling pathway ubiquitination proteosomal degradation |
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