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Optimum designs for non‐linear mixed effects models in the presence of covariates
Authors:Barbara Bogacka  Mahbub A. H. M. Latif  Steven G. Gilmour  Kuresh Youdim
Affiliation:1. School of Mathematical Sciences, Queen Mary, University of London, London E1 4NS, UK;2. Institute of Statistical Research and Training, University of Dhaka, Dhaka‐1000, Bangladesh;3. Center for Clinical Epidemiology, St Luke's International University, Chuo‐ku, Tokyo 104‐0045, Japan;4. Department of Mathematics, King's College London, Strand, London WC2R 2LS, UK;5. Roche Pharmaceutical Research and Early Development, Pharmaceutical Sciences, Roche Innovation Center Basel, F. Hoffmann‐La Roche Ltd, Grenzacherstrasse 124, 4070 Basel, Switzerland
Abstract:
Keywords:Design of experiments  Enzyme kinetics  Fisher Information  Planning experiments  Random effects model
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