Intersection of autophagy with pathways of antigen presentation |
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| Authors: | Natalie L. Patterson Justine D. Mintern |
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| Affiliation: | Department of Biochemistry and Molecular Biology, The University of Melbourne, Parkville, Victoria 3010, Australia |
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| Abstract: | Traditionally, macroautophagy (autophagy) is viewed as a pathway of cell survival. Autophagy ensures the elimination of damaged or unwanted cytosolic components and provides a source of cellular nutrients during periods of stress. Interestingly, autophagy can also directly intersect with, and impact, other major pathways of cellular function. Here, we will review the contribution of autophagy to pathways of antigen presentation. The autophagy machinery acts to modulate both MHCI and MHCII antigen presentation. As such autophagy is an important participant in pathways that elicit host cell immunity and the elimination of infectious pathogens. |
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| Keywords: | autophagy antigen presentation antigen presenting cells dendritic cells MHCI MHCII |
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