Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis |
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| Authors: | Yuan Yuan Peng Li Jing Ye |
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| Affiliation: | 1. Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China; 2. Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084, China |
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| Abstract: | Atherosclerosis is a chronic, inflammatory disorder characterized by the deposition of excess lipids in the arterial intima. The formation of macrophage-derived foam cells in a plaque is a hallmark of the development of atherosclerosis. Lipid homeostasis, especially cholesterol homeostasis, plays a crucial role during the formation of foam cells. Recently, lipid droplet-associated proteins, including PAT and CIDE family proteins, have been shown to control the development of atherosclerosis by regulating the formation, growth, stabilization and functions of lipid droplets in macrophage-derived foam cells. This review focuses on the potential mechanisms of formation of macrophage-derived foam cells in atherosclerosis with particular emphasis on the role of lipid homeostasis and lipid droplet-associated proteins. Understanding the process of foam cell formation will aid in the future discovery of novel therapeutic interventions for atherosclerosis. |
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| Keywords: | macrophage foam cell atherosclerosis cholesterol lipid droplet-associated proteins |
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