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Association of Allergic Symptoms with Dengue Infection and Severity: A Systematic Review and Meta-analysis |
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| Authors: | Kien Nguyen Dang El-Qushayri Amr Ehab Ahmed Ali Mahmoud Safi Adnan Mageed Sarah Abdel Mehyar Samar Muhammed Hashan Mohammad Rashidul Karimzadeh Sedighe Hirayama Kenji Huy Nguyen Tien |
| Affiliation: | 1.Department of Obstetrics and Gynecology, Thai Binh University of Medicine and Pharmacy, Thai Binh, 410000, Vietnam ;2.Online Research Club (http://www.onlineresearchclub.org/), Nagasaki, Japan ;3.Faculty of Medicine, Minia University, Minia, 61519, Egypt ;4.Faculty of Medicine, Al-Azhar University, Cairo, 11865, Egypt ;5.Nishtar Medical University, Multan, 60000, Pakistan ;6.Faculty of Medicine, Tanta University, Tanta, 31511, Egypt ;7.Istishari Hospital, Amman, 11953, Jordan ;8.Infectious Disease Division, Respiratory and Enteric Infections Department, International Center for Diarrheal Disease Research, Dhaka, GPO Box 128, Dhaka, 1000, Bangladesh ;9.School of Medicine, Sabzevar University of Medical Sciences, Sabzevar, 00989156113915, Iran ;10.Department of Immunogenetics, Institute of Tropical Medicine (NEKKEN), Leading Graduate School Program, and Graduate School of Biomedical Sciences, Nagasaki University, 1-12-4 Sakamoto, Nagasaki, 852-8523, Japan ;11.Evidence Based Medicine Research Group, Ton Duc Thang University, Ho Chi Minh City, 70000, Vietnam ;12.Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, 70000, Vietnam ; |
| Abstract: | The relationship between the severity of dengue infection and allergy is still obscure. We conducted an electronic search across 12 databases for relevant articles reporting allergic symptoms, dengue infection, and dengue classification. These studies were categorized according to dengue severity and allergy symptoms, and a meta-analysis was performed by pooling the studies in each category. Among the included 57 articles, pruritus was the most common allergic sign followed by non-specified allergy and asthma(28.6%, 13%, and 6.5%, respectively). Despite the reported significant association of dengue with pruritus and total Ig E level(P 0.05), in comparison with non-dengue cases and healthy controls, there was no association between the different severe dengue group with pruritus, skin allergy, food allergy or asthma. However,removing the largest study revealed a significant association between asthma with dengue hemorrhagic fever(DHF) rather than dengue fever(DF). In comparison with DF, DHF was associated with Ig E positivity. Furthermore, specific-Ig E level was higher in secondary DF rather than primary DF. There was a possible association between allergy symptoms and dengue severity progression. Further studies are needed to clarify this association. |
| Keywords: | Dengue Allergy Severity IgE Asthma Association |
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