Polymorphisms of 20 regulatory proteins between Mycobacterium tuberculosis and Mycobacterium bovis |
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| Authors: | María M. Bigi Federico Carlos Blanco Flabio R. Araújo Tyler C. Thacker Martín J. Zumárraga Angel A. Cataldi Marcelo A. Soria Fabiana Bigi |
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| Affiliation: | 1. School of Agronomy, UBA, Buenos Aires 1417, Argentina;2. Biotechnology Institute, National Institute of Agricultural Technology (INTA), Argentina;3. EMBRAPA, Mato Grosso do Sul 8605, Brazil;4. United States Department of Agriculture, Agricultural Research Service, National Animal Disease Center, Ames, Iowa 50010, USA |
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| Abstract: | Mycobacterium tuberculosis and Mycobacterium bovis are responsible for tuberculosis in humans and animals, respectively. Both species are closely related and belong to the Mycobacterium tuberculosis complex (MTC). M. tuberculosis is the most ancient species from which M. bovis and other members of the MTC evolved. The genome of M. bovis is over >99.95% identical to that of M. tuberculosis but with seven deletions ranging in size from 1 to 12.7 kb. In addition, 1200 single nucleotide mutations in coding regions distinguish M. bovis from M. tuberculosis. In the present study, we assessed 75 M. tuberculosis genomes and 23 M. bovis genomes to identify non‐synonymous mutations in 202 coding sequences of regulatory genes between both species. We identified species‐specific variants in 20 regulatory proteins and confirmed differential expression of hypoxia‐related genes between M. bovis and M. tuberculosis. |
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| Keywords: | Mycobacterium bovis Mycobacterium tuberculosis polymorphism regulator |
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