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Mutations in the hemagglutinin receptor-binding site can change the biological properties of an influenza virus |
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| Authors: | C W Naeve V S Hinshaw R G Webster |
| Abstract: | Avian influenza virus reassortants containing human influenza virus hemagglutinins do not replicate in ducks. Two mutations in the receptor-binding site of a human hemagglutinin at residues 226 and 228 allowed replication in ducks. The mutations resulted in a receptor-binding-site sequence identical to the known avian influenza virus sequences. |
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