A novel subgenomic murine leukemia virus RNA transcript results from alternative splicing |
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| Authors: | Déjardin J Bompard-Maréchal G Audit M Hope T J Sitbon M Mougel M |
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| Affiliation: | Institut de Génétique Moléculaire de Montpellier, IFR 24, CNRS-UMR5535, and Université Montpellier II, F-34293 Montpellier Cedex 5, France. |
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| Abstract: | Here we show the existence of a novel subgenomic 4.4-kb RNA in cells infected with the prototypic replication-competent Friend or Moloney murine leukemia viruses (MuLV). This RNA derives by splicing from an alternative donor site (SD') within the capsid-coding region to the canonical envelope splice acceptor site. The position and the sequence of SD' was highly conserved among mammalian type C and D oncoviruses. Point mutations used to inactivate SD' without changing the capsid-coding ability affected viral RNA splicing and reduced viral replication in infected cells. |
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