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Amplification and expression of a cellular oncogene (c-myc) in human gastric adenocarcinoma cells. |
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| Authors: | M Shibuya J Yokota Y Ueyama |
| Abstract: | Three of 16 human gastric adenocarcinoma samples, maintained as solid tumors in nude mice, were found to carry amplified c-myc genes. In two samples with a high degree of c-myc DNA amplification (15- to 30-fold), double minute chromosomes were observed in karyotype analysis. The level of c-myc RNA was markedly elevated in a rapidly growing and poorly differentiated tumor, whereas it was only slightly elevated in a slowly growing and more differentiated tumor. |
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