Elevated rates of sister chromatid exchange at chromosome ends |
| |
| Authors: | Rudd M Katharine Friedman Cynthia Parghi Sean S Linardopoulou Elena V Hsu Li Trask Barbara J |
| |
| Affiliation: | Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America. |
| |
| Abstract: | Chromosome ends are known hotspots of meiotic recombination and double-strand breaks. We monitored mitotic sister chromatid exchange (SCE) in telomeres and subtelomeres and found that 17% of all SCE occurs in the terminal 0.1% of the chromosome. Telomeres and subtelomeres are significantly enriched for SCEs, exhibiting rates of SCE per basepair that are at least 1,600 and 160 times greater, respectively, than elsewhere in the genome. |
| |
| Keywords: | |
| 本文献已被 PubMed 等数据库收录！ |
|
