Changes in brown-adipose-tissue mitochondrial processes in streptozotocin-diabetes. |
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| Authors: | Z Jamal and E D Saggerson |
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| Affiliation: | Departamento de Bioquímica y Biología Molecular (Veterinaria), Universidad de Córdoba, Spain. |
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| Abstract: | Yeast glucose-6-phosphate dehydrogenase was inhibited by low NADPH concentrations in cell-free extracts, and de-inhibited by GSSG; extensive dialysis of the crude extract did not diminish the GSSG effect. Immunoprecipitation of glutathione reductase abolished the de-inhibition of glucose-6-phosphate dehydrogenase by GSSG. Purified glucose-6-phosphate dehydrogenase was inhibited by NADPH but not de-inhibited by GSSG, and upon addition of pure glutathione reductase GSSG completely de-inhibited the glucose-6-phosphate dehydrogenase. |
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