Excision of the Shigella resistance locus pathogenicity island in Shigella flexneri is stimulated by a member of a new subgroup of recombination directionality factors |
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| Authors: | Luck Shelley N Turner Sally A Rajakumar Kumar Adler Ben Sakellaris Harry |
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| Affiliation: | Australian Bacterial Pathogenesis Program, Department of Microbiology, Monash University, Clayton 3800, Australia. |
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| Abstract: | Pathogenicity islands are capable of excision and insertion within bacterial chromosomes. We describe a protein, Rox, that stimulates excision of the Shigella resistance locus pathogenicity island in Shigella flexneri. Sequence analysis suggests that Rox belongs to a new subfamily of recombination directionality factors, which includes proteins from P4, enterohemorrhagic Escherichia coli, and Yersinia pestis. |
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