| EGFR的表达与头颈部鳞癌放射敏感性的相关性研究进展 |
| |
| 引用本文： | 庄明,鄂明艳. EGFR的表达与头颈部鳞癌放射敏感性的相关性研究进展[J]. 现代生物医学进展, 2012, 12(17): 3350-3353 |
| |
| 作者姓名： | 庄明 鄂明艳 |
| |
| 作者单位： | 哈尔滨医科大学附属第三临床医学院放疗四病区 黑龙江哈尔滨150081 |
| |
| 摘 要： | 表皮生长因子受体(epidermal growth factor receptor,EGFR)在相当一部分的人类肿瘤细胞存在过表达,EGFR的活化及过度表达影响着肿瘤细胞的增殖、侵袭、转移及与肿瘤对化疗和放疗的耐受相关,且对预后有着重要影响。本文主要述EGFR的结构及其功能、基因多态性,EFGR引起放疗抗拒的作用机制,EGFR在头颈部鳞癌组织中的表达,及对其放射敏感性的影响。探讨EGFR阻滞剂在临床中的应用前景。
|
| 关 键 词： | EGFR 头颈部鳞癌 放射敏感性 EGFR阻滞剂 |
Expression of EGFR and Progress of Study on the Correlation of Radiosensitivity in Head and Neck Squamous Cell Carcinoma |
| |
| ZHUANG Ming , E Ming-yan. Expression of EGFR and Progress of Study on the Correlation of Radiosensitivity in Head and Neck Squamous Cell Carcinoma[J]. Progress in Modern Biomedicine, 2012, 12(17): 3350-3353 |
| |
| Authors: | ZHUANG Ming E Ming-yan |
| |
| Affiliation: | (The Third Affiliated Hospital of Harbin Medical University,Radiotherapy of fourth ward,Heilongjiang,Harbin,150081) |
| |
| Abstract: | Epidermal growth factor receptor(EGFR) expression exists in considerable part of human tumor cells,activation and overexpression of EGFR affects tumor cell proliferation,invasion and metastasis and tolerances to chemotherapy and radiotherapy of tumor-related,and has an important implications for prognosis.This paper mainly described the structure and function of EGFR,gene polymorphisms,EGFR mechanism of action of radiation resist,EGFR expression in head and neck Squamous Cell Carcinoma,and its effect on radiation sensitivity.This paper also explored EGFR blockers in clinical application prospect. |
| |
| Keywords: | EGFR Head and neck squamous cell carcinoma Radiation sensitivity EGFR blockers |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
