The many faces of mitophagy |
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| Authors: | Rachael M Ivatt Alexander J Whitworth |
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| Affiliation: | Department of Biomedical Science, MRC Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield, UK |
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| Abstract: | Failure to maintain mitochondrial integrity is linked to age‐related conditions, such as neurodegeneration. Two genes linked to Parkinson's disease, PINK1 and Parkin, play a key role in targeting the degradation of dysfunctional mitochondria (mitophagy). However, the mechanisms regulating the PINK1/Parkin pathway and other processes that impinge on mitochondrial turnover are poorly understood. Two articles in EMBO reports, by the Przedborski and Ganley groups 1 2 , shed light on a new role for processed, cytoplasmic PINK1, and show that depletion of cellular iron levels stimulates PINK1/Parkin‐independent mitophagy. |
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