Toxoplasma gondii Hsp70 as a danger signal in toxoplasma gondii-infected mice |
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| Authors: | Mun H S Aosai F Norose K Chen M Hata H Tagawa Y I Iwakura Y Byun D S Yano A |
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| Affiliation: | Department of Parasitology, Chiba University School of Medicine, Japan. |
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| Abstract: | Toxoplasma gondii Hsp70, T gondii Hsp30/bag1, and surface antigen 1 messenger RNAs were shown to be useful in analyzing stage conversion of T gondii between bradyzoites and tachyzoites. The high-level expression of T gondii Hsp70 was correlated with mortality in interferon-gamma knockout mice infected with T gondii. Tgondii Hsp70 inhibited the induction of nitric oxide release by peritoneal macrophages of T gondii-infected mice. These findings identify T gondii Hsp70 as a danger signal during lethal, acute T gondii infection. |
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