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Colchicine inhibition of the heparin-stimulated release of clearing-factor lipase from isolated fat-cells. |
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| Authors: | A Cryer A McDonald E R Williams D S Robinson |
| Abstract: | When isolated fat-cells are incubated at 25 degrees C in serum-based media containing glucose, insulin and heparin, the rise that occurs in the clearing-factor lipase activity of the incubation medium is inhibited by colchicine. The rise in the fat-cell clearing-factor lipase activity that occurs during similar incubations in the absence of heparin is not affected by colchicine. |
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