| A Brief Review of Short Tandem Repeat Mutation |
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| 作者姓名： | Fan H Chu JY |
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| 作者单位： | [1]Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming 650118, China [2]Biochemistry Department, Kunming Medical College, Kunming 650031, China |
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| 摘 要： | Short tandem repeats （STRs） are short tandemly repeated DNA sequences that involve a repetitive unit of 1-6 bp. Because of their polymorphisms and high mutation rates, STRs are widely used in biological research. Strand-slippage replication is the predominant mutation mechanism of STRs, and the stepwise mutation model is regarded as the main mutation model. STR mutation rates can be influenced by many factors. Moreover, some trinucleotide repeats are associated with human neurodegenerative diseases. In order to deepen our knowledge of these diseases and broaden STR application, it is essential to understand the STR mutation process in detail. In this review, we focus on the current known information about STR mutation.
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| 关 键 词： | 衔接重复 突变 DNA序列分析 遗传多态性 |
A brief review of short tandem repeat mutation |
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| Fan H,Chu JY.A Brief Review of Short Tandem Repeat Mutation[J].Genomics Proteomics & Bioinformatics,2007,5(1):7-14. |
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| Authors: | Fan Hao Chu Jia-You |
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| Institution: | Institute of Medical Biology, Chinese Academy of Medical Sciences, Kunming 650118, China. |
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| Abstract: | Short tandem repeats (STRs) are short tandemly repeated DNA sequences that involve a repetitive unit of 1-6 bp. Because of their polymorphisms and high mutation rates, STRs are widely used in biological research. Strand-slippage replication is the predominant mutation mechanism of STRs, and the stepwise mutation model is regarded as the main mutation model. STR mutation rates can be influenced by many factors. Moreover, some trinucleotide repeats are associated with human neurodegenerative diseases. In order to deepen our knowledge of these diseases and broaden STR application, it is essential to understand the STR mutation process in detail. In this review, we focus on the current known information about STR mutation. |
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| Keywords: | short tandem repeats mutation Mutation Short Tandem Repeat focus current known information review essential process order knowledge neurodegenerative diseases application associated human factors mutation model replication mechanism widely |
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