氚—烟酰苯胺在钉螺体内分布示踪的研究

本文应用氚－烟酰苯胺标记湖北钉螺，示踪观察不同时间烟酰苯胺进入螺体组织和脏器内的分布和进入途径。结果显示，钉螺接触药物从２２分钟开始检测出组织、脏器内氚含量，以后逐渐增高，至１４４０分钟达最高峰；合计不同时间各组织和脏器中药物含量由高至低排列次序为外套膜、胃肠、肝脏、肠内粪梗、睾丸、卵巢、鳃、神经节、心脏；转换氚含量为烟酰苯胺剂量，证实了烟酰苯胺杀螺的低用量与高效性；由单位重量组织和脏器中药物含量排位，反映出药物在螺体分布动态变化，以及药物通过消化系统、呼吸系统、外套膜表皮三条途径进入。

STUDY ON DISTRIBUTION OF TRITIUM-NICOTINANILIDE IN THE BODY OF ONCOMELANIA HUPENSIS

The study refered to the distribution of Tritium-Nicotinanilide in the snails of Oncomelania hupensis labelled. The way of approach into snail tissues and organs of Tritium-Nicotinanilide in snail bodies by tracer method at different intervals were also observed. The results showed that 1)the Tritium-Nicotinanilide entered the bodies of snails from mouth, jaw, and tegument of the snail. 2) the Tritium-Nicotinanilide was detected in the tissues and organs of the snails 22 minutes later after snails contacted it. The concentration peak of the Tritium-Niconanilide in the bodies of snails was appeared at 1440 minutes.3) the content of Tritium-Nicotinailide in tissues and organs of the snails was different, it was depended on the time contacted and the dose.This experiment showed that the nicotinanilide was an effective molluscide, it can kill mollusks with low dose.