| 冷暴露对中缅树鼩褐色脂肪组织中解偶联蛋白1含量的影响 |
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| 引用本文： | 谢静,王政昆,张武先,朱莉萍.冷暴露对中缅树鼩褐色脂肪组织中解偶联蛋白1含量的影响[J].动物学杂志,2008,43(4):34-40. |
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| 作者姓名： | 谢静 王政昆 张武先 朱莉萍 |
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| 作者单位： | 云南师范大学生命科学学院教育部生物能源持续开发利用工程研究中心,昆明,650092 |
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| 基金项目： | 国家自然科学基金，云南省科技强省研究重点项目 |
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| 摘 要： | 自备抗血清采用酶联免疫法测定了中缅树鼩(Tupaia belangeri)在(5±1)℃冷暴露0 d、7 d、14 d、21d、28 d时,褐色脂肪组织(BAT)中解偶联蛋白1(UCP1)的含量.结果表明,随着冷暴露时间的延长,中缅树鼩的体重、褐色脂肪组织重量均表现出了增加的趋势,BAT线粒体总蛋白和UCP1的含量也呈增加的趋势,其中UCP1的含量在28 d时达到极显著水平,比对照组增加了55.9%.说明冷暴露能够诱导中缅树鼩UCP1表达增加,从而使其适应性产热增加.
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| 关 键 词： | 中缅树鼩 冷暴露 解偶联蛋白-1 酶联免疫 |
| 收稿时间： | 2007/12/26 0:00:00 |
| 修稿时间： | 2008/4/28 0:00:00 |
The Effects of Cold Exposure on the Content of Uncoupling Protein of BAT in Tupaia belangeri |
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| XIE Jing,WANG Zheng-Kun,ZHANG Wu-Xian and ZHU Li-Ping.The Effects of Cold Exposure on the Content of Uncoupling Protein of BAT in Tupaia belangeri[J].Chinese Journal of Zoology,2008,43(4):34-40. |
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| Authors: | XIE Jing WANG Zheng-Kun ZHANG Wu-Xian and ZHU Li-Ping |
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| Institution: | XIE Jing WANG Zheng-Kun ZHANG Wu-Xian ZHU Li-Ping(School of Life Science of Yunnan Normal University,Engineering Research Center of Sustainable Development , Utilization of Biomass Energy Ministry of Education,Kunming 650092,China) |
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| Abstract: | Uncoupling proteins(UCPs) increase proton leakage across the inner mitochondrial membrane.UCP1 in brown adipose tissue dissipates proton motive force as heat.This mechanism of nonshivering thermogenesis is considered as a monophyletic trait of endothermic placental mammals and provided a crucial advantage for life in the cold.Thereby,UCP1 is thus the only protein capable of mediating cold-acclimation-recruited adaptive adrenergic nonshivering thermogenesis.In this study,the content of UCP1 in BAT in Tree Sh... |
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| Keywords: | Tupaia belangeri Cold acclimation Uncoupling protein-1 Enzyme-linked immunosorbent assay |
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