卵透明带ZP3的研究及其应用

卵透明带蛋白围绕在卵母细胞外，在受精过程中起着重要作用。ZP3蛋白是卵透明带蛋白家族中的重要成员，在功能上，ZP3作为初级精子受体，起始精卵结合和顶体反应。由于ZP3在受精中的重要作用，它成为免疫避孕的有效靶点。ZP3蛋白疫苗和DNA疫苗可以诱导机体产生较强的免疫反应，导致生育降低，同时带来一定程度的副作用。本文重点介绍了ZP3的免疫特性及其应用。

Studies and Applications of Zona Pellucida 3

Zona pellucida protein surrounding to oocyte is important in the proc ess of fertilization. ZP3 protein is one of the ZP family.It acts as the primary receptor for sperm, initiating the binding of sperm and egg and acrosome react ion as well. Because of its key role in fertilization, it is regarded as the tar get of immunocontraception. Both ZP3 protein vaccine and DNA vaccine can elicit immune responses and result in subsequent infertility, but at the same time caus e some structural abnormality. Here we introduce the immunological property and application of the ZP3.